Visualize flow in Minutes!
Time is Money! Computational Tools / Software are used to solve Partial Differential Equations (PDE) with the help of numerical methods and discretization of elements into grids, commonly known as mesh. Analysis of fluid behavioral patterns, known as Computational Fluid Dynamics (CFD), aims at solving Navier-Stokes (N-S) Equation coupled with boundary conditions. There are a…
Bioreactor Characterization – Asset Library
Before we get into what’s the need for an Asset Library, let’s revisit the importance of Asset Characterization in technology transfer and Scale Up Process! Asset Characterization is an important step in determining the process performance capability of an equipment. Using Computational Tools / Software to characterize assets has reduced considerable time in planning future…
Asset Characterization with Interactive Webapps
Webapps are a great tool to create an interactive interface to visualizing the interaction of Process Parameters (PP), Process Metrics (PM) and Quality Attributes (QA). Let’s say we have a database of assets with it’s credential information and operating parameters. Next step is to access the information in an organized form, and an interactive webapp…
Scale-up of Bioreactors: Revisiting the Heuristics
“It is paradoxical, yet true, to say, that the more we know, the more ignorant we become in the absolute sense, for it is only through enlightenment that we become conscious of our limitations. Precisely one of the most gratifying results of intellectual evolution is the continuous opening up of new and greater prospects.” -Nikola…
Process Metrics for Feature Engineering
Using Feature Engineering to analyze Process Metrics can save time and resources, leading to faster execution of process scale up projects.
Simple Webapps For Fundamental Process Understanding
Ever wished for a way of easy dashboard reporting of advanced analysis across the organization with interactive abilities? Simple webapps are the perfect solution to that! They can be easily created in Python, executed with Voila (Jupyter environment native) and deployed over the air (OTA) with just a simple internet link. So what exactly is…
Scale-Up of Bioreactors: Have You ‘Understood’ Your Assets Yet?
“I believe that thirty million of these animalcules together would not take up as much room, or be as big, as a coarse grain of sand.” -Antoine van Leeuwenhoek, 1632 to 1723 The advent of biotechnology marked one of the greatest revolutions in the history of mankind, undeniably the biggest one since the industrial revolution…
Process Metrics – The Keystone Of Process Understanding
Process metrics or PMs, are characteristics of a pharmaceutical process that are critical to ensuring product quality and process performance. They are characteristics of the processing ‘micro-environment’ for a given unit operations equipment or ‘process asset’. Generally speaking, maintaining these CPMs at the same (or nearly same) values across scales is a necessary condition for…
Asset Characterization : Digital Nameplating Of Assets
Asset characterization is an important step in determining the process performance capability of a given unit operations equipment. As we saw in an earlier post, it forms the backbone of process understanding and science-driven development/transfer. Lets recap things a bit here: asset characterization can be performed conveniently using computational/first-principles models. this results in a digital…
Process Signatures : How You Can Stop Worrying and Start Loving Scale-up
Process signatures capture the scale-independent relationships for a given unit operation or unit process. They represent scale-up or transfer rules that can be used to seamlessly move processes from one equipment to another, from site to another etc. Process signatures are based on the tenet that achieving process similarity is the same as achieving similarity…
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Process Science For The Pharma Industry 